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School dietician Edna Garrett, played by Charlotte Rae, mentored and guided four girls: the snobby rich Blair Warner (Lisa Welchel), gossiping Tootie Ramsey (Kim Fields), impressionable Natalie Green (Mindy Cohn), and Jo Polniaczek (Nancy McKeon) at the all exclusive private boarding school, Eastland Academy, in Peekskill, New York. After somewhat of a slow start, the show found its audience and became one of the longest running sitcoms of the 1980's era and in television history to feature an all-female-cast.

As all sitcoms get older, they evolve over time. The girls graduated from Eastland Academy. Mrs. Garrett opened her own gourmet food shop, Edna's Edibles which later evolved into the 1950's style malt shop called Over Our Heads In 1986, Charlotte Rae, decided to leave the show feeling that the girls had out grown Mrs. Garrett's advice. Her replacement was Cloris Leachman; who played energetic and not so wise sister, Beverly Ann Stickle.

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